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US 2024/0189243 A1Published application
Lipid compound or a derivative thereof and pharmaceutical composition employing the same
AssigneeIndustrial Technology Research Institute
InventorsFelice Cheng, Ping-Fu Cheng, Jenn-Tsang Hwang, Chih-Wei Fu, Ku-Feng Lin, Ya-Ling Chiu, Jheng-Sian Li, Kang-Li Wang, Siou-Han Chang, Chia-Yu Fan
Life of this patent
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Abstract
A lipid compound or a derivative thereof and a pharmaceutical composition employing the same are provided. The lipid compound has a structure represented by Formula (I): wherein Z1, Z2, Z3 and Z4 are as disclosed in the specification.
Claims18
A lipid compound or a derivative thereof, wherein the lipid compound has a structure represented by Formula (I):
- wherein Z1 is O or S;
- Z2 is -Q1-A1-Q2-A2-X1;
- Z3 and Z2 are the same;
- Z4 is -Q3-A3-Q4-A4-X2;
- each of Q1 and Q3 is independently a single bond, —O— or —NH—;
- each of Q2 and Q4 is independently a single bond, —O—, —NH—, —S—S—,
- A1 is C1-C6 alkylene group;
- A3 is a single bond or a C1-C6 alkylene group;
- each of A2 and A4 is independently a single bond, a C1-C12 alkylene group, a C2-C12 alkenylene group or a C2-C12 alkynylene group;
- X1 is hydrogen, a C1-C24 alkyl group, a C2-C24 alkenyl group, a C2-C24 alkynyl group, a C1-C24 alkanol group, a C2-C24 alkenol group, a C2-C24 alkynol group, —NR1R2,
- X2 is hydrogen, a C6-C12 aryl group, a C1-C24 alkyl group, a C2-C24 alkenyl group, a C2-C24 alkynyl group, a C1-C24 alkanol group, a C2-C24 alkenol group, a C2-C24 alkynol group, —NR7R8,
- R1 is hydrogen, a C1-C24 alkyl group, a C2-C24 alkenyl group, a C2-C24 alkynyl group, a C1-C24 alkanol group, a C2-C24 alkenol group, a C2-C24 alkynol group or -A9-Q7-X5;
- R2 is hydrogen, a C1-C24 alkyl group, a C2-C24 alkenyl group, a C2-C24 alkynyl group, a C1-C24 alkanol group, a C2-C24 alkenol group, a C2-C24 alkynol group or -A10-Q8-X6;
- each of R3, R4, R5, R6, R9, R10, R11 and R12 is independently hydrogen or a C1-C6 alkyl group;
- R7 is hydrogen, a C1-C24 alkyl group, a C2-C24 alkenyl group, a C2-C24 alkynyl group, a C1-C24 alkanol group, a C2-C24 alkenol group, a C2-C24 alkynol group or -A11-Q9-X7;
- R8 is hydrogen, a C1-C24 alkyl group, a C2-C24 alkenyl group, a C2-C24 alkynyl group, a C1-C24 alkanol group, a C2-C24 alkenol group, a C2-C24 alkynol group or -A12-Q10-X8;
- each of A5, A6, A7, A8, A9, A10, A11 and A12 is independently a C1-C12 alkylene group;
- each of Q5, Q6, Q7, Q8, Q9 and Q10 is independently —O—, —NH—, —S—S—,
- and each of X3, X4, X5, X6, X7 and X8 is independently a C1-C24 alkyl group.
16 more elements
Dependencies are inferred from the claim text.