# US 2024/0189201 A1 · Hair serum and supplement

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- Number: US 2024/0189201 A1
- Document ID: US20240189201A1
- Status: Published application
- Kind: A1
- Application number: 18/286,990
- Filed: 2022-04-13
- Published: 2024-06-13
- Earliest claimed: 2021-04-13
- Assignees: CS Medica A/S
- Applicants: Cs Medica A/S
- Inventors: Lone HENRIKSEN
- Web page: https://patentgrep.com/patent/US20240189201A1

## CPC

- A61K 8/345: {containing more than one hydroxy group}
- A61Q 7/00: Preparations for affecting hair growth
- A61K 8/27: Zinc; Compounds thereof
- A61K 8/34: Alcohols
- A61K 8/347: {Phenols}
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/602: {Glycosides, e.g. rutin}
- A61K 8/675: {Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde (tocopheryl nicotinate A61K8/678)}
- A61K 31/095: Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/52: Purines, e.g. adenine
- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- A61K 33/30: Zinc; Compounds thereof
- A61P 17/14: for baldness or alopecia
- A61Q 5/002: {Preparations for repairing the hair, e.g. hair cure}
- A61K 2800/48: Thickener, Thickening system
- A61K 2800/92: Oral administration
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a hair serum and supplement for use in the treatment and/or alleviation of skin and/or hair-related symptoms and/or condition, comprising dandruff, weakening and/or breaking nails or hair, including hair-loss. Treatments may comprise application of a cannabinoid-comprising topical composition, such as a cannabidiol- and low molecular weight alcohol composition e.g. formulated as a serum, and/or consumption of a supplement comprising e.g. vitamins, zinc, selenium and amino acids, such as one or more S-comprising amino acid(s).

## Claims

### Claim at position 1

-62. (canceled)

### Claim 63

A composition comprising:
Cannabidiol (CBD);
Redensyl®;
Capixyl®; and
a C3 to C8 diol.

### Claim 64 (depends on 63)

The composition according to claim 63, wherein:
Redensyl® comprises dihydroquercetin-glucoside, epigallotechin gallate-glucoside, glycine, zinc chloride, meta-bisulfite, and glycerin; and
Capixyl® comprises butylene glycol, dextran, acetyl tetrapeptide-3, Trifolium pratense flower extract.

### Claim 65 (depends on 63)

The composition according to claim 63, wherein the C3 to C8 diol comprises 1, 5 pentanediol.

### Claim 66 (depends on 63)

The composition according to claim 63 comprising:
menthol;
a skin healing compound comprising hyaluronic acid/hyaluronate;
caffeine;
propylene glycol;
a skin conditioning agent or emollient, a binder comprising isopropyl palmitate, or both a binder and a skin conditioning agent or emollient;
triethanolamine;
arginine;
panthenol;
EtOH;
a vitamin comprising a B vitamin, wherein the B vitamin comprises vitamin B7; an adjusting agent comprising citric acid monohydrate;
a skin healing compound comprising hyaluronic acid/hyaluronate;
a thickening agent comprising Xanthan gum; or
any combination thereof.

### Claim 67 (depends on 65)

The composition according to claim 65 comprising a concentration (% by weight) of:
0.001-2.0, 0.05-0.5, 0.075-0.2, or around 0.1% CBD;
10-60, 30-55, 40-50, or around 30% EtOH;
0.5-5.0, 1.0-4.0, 1.5-2.5, or around 2% C3-C8 diol;
0.1-2.0, 0.2-1.0, 0.4-0.8, or around 0.6% menthol;
0.01-2.0, 0.1-1.5, 0.85-1.15, or around 0.95% of a skin healing compound comprising hyaluronic acid/hyaluronate;
0.01-2.0%, 0.02-0.5, 0.04-0.07, or around 0.05% caffeine;
1.0-20, 2-10, 4-6, or around 5.0% propylene glycol;
1.0-20, 2-15, 5-8, or around 6.5% glycerin;
0.05-2.0, 0.1-1.0, 0.7-1.2, or 0.9% of a moisturizer, an emollient, a binder comprising isopropyl palmitate, or any combination of a moisturizer, an emollient and a binder;
0.1-2.0, 0.15-1.0, 0.2-0.4, or around 0.28% triethanolamine;
0.0001-1.0, 0.0005-0.1, 0.001-0.003, or around 0.002% arginine;
0.5-5.0, 1.0-4.0, 2.5-3.0, or around 2.7% panthenol;
0.1-2.0, 0.2-1.5, 0.8-1.2, or around 1.0% of a vitamin B;
0.1-2.0, 0.15-1.0, 0.15-0.4, or around 0.25% of a thickening agent;
or any combination thereof.

### Claim 68 (depends on 63)

The composition of claim 63 comprising an amount of water suitable for formulating a hair serum with the composition, wherein the amount of water suitable for formulating a hair serum with the composition is 30-70%, 35-60%, 40-55%, or around 45% water.

### Claim 69 (depends on 63)

The composition of claim 63 essentially free of cannabinoids other than Cannabidiol (CBD).

### Claim 70 (depends on 63)

The composition of claim 63 wherein said composition is essentially free of one or more cannabinoids comprising:
THC (tetrahydrocannabinol), THCA (tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), CBN (cannabinol), CBG (cannabigerol), CBC (cannabichromene), CBL (cannabicyclol), CBV (cannabivarin), THCC (tetrahydrocannabiorcol), THCV (tetrahydrocannabivarin), THCP (tetrahydrocannabiphorol), CBDV (cannabidivarin), CBCV (cannabichromevarin), CBGV (cannabigerovarin), CBGM (cannabigerol monomethyl ether), CBE (cannabielsoin), CBT (cannabicitran), including one or more cannabinoids of the following types: CBG-type, CBC-type, CBD-type other than CBD, THC-type, CBN-type, CBE-type, iso-THC-type, CBL-type, CBT-type, or any combination thereof.

### Claim 71 (depends on 63)

The composition of claim 63 comprising:
one or more cannabinoids in addition to CBD provided in an amount below 10, 5, 2, 1, 0.5, or 0.1% by weight in relation to % by weight of CBD in the composition; or
one or more cannabinoids in addition to CBD provided in a ratio to CBD in the composition of: >100:1, 100:1-50:1, 50:1-25:1, 25:1-10:1, 10:1, 10:1-5:1, 5:1-2:1, 2:1-1:1, 1:1-1:2, 1:2-1:5, or <1:5.

### Claim 72 (depends on 63)

A method for treatment of an affected surface on a subject having a hair, scalp, skin, or nail condition comprising:
providing a composition as defined in claim 63 formulated as a topical preparation to the affected surface on the subject, wherein said subject is a human or non-human animal; and
providing a treatment to the affected surface of the subject.

### Claim 73 (depends on 72)

The method of claim 72, wherein the topical preparation is formulated as a hair serum, and the hair, scalp, skin, or nail condition of the subject is:
Androgenic Alopecia;
Telogen effluvium;
Anagen effluvium; or
Alopecia traction.

### Claim 74 (depends on 72)

The method of claim 72 further comprising providing a supplement to the subject, wherein said supplement comprises a vitamin, an amino acid, zinc, selenium, or any combination thereof, and is formulated as an oral dosage form.

### Claim 75 (depends on 74)

The method of claim 74 wherein the supplement comprises:
B vitamins comprising Vitamin B5 (Pantothenic acid), Vitamin B6, Vitamin B7, Vitamin B12, or any combination thereof;
Zinc comprising Zinc gluconate;
Selenium comprising L-Selenium methionine; and
Amino acids comprising an S-amino acid, wherein said S-amino acid comprises L-Methionine, L-Cysteine, L-Cystine, or any combination thereof.

### Claim 76 (depends on 75)

The method of claim 75, wherein said supplement comprises one or more of the following ingredients in a % by weight of:
0.5-10% Vitamin B, said Vitamin B comprising:
0.5-5.0, 0.8-3.0, or 1.0-1.5, or around 1.3% Vitamin B5;
0.01-2.0, 0.1-1.5, 0.2-0.4, or around 0.28% Vitamin B6;
0.1-2.0, 0.15-1.0, 0.20-0.5, or around 0.35% Vitamin B7;
0.00005-2.0, 0.0001-1.0, 0.0002-0.0004, or around 0.0003% Vitamin B12; or any combination thereof;
0.1-2.0, 0.2-1.0, 0.4-0.7, or around 0.55% Zinc comprising Zinc gluconate;
0.001-2.0, 0.005-1.0, 0.0075-0.015, or around 0.01% Selenium comprising L-Selenium methionine; and
25-90% Amino acid(s) comprising one or more S-amino acids, said S-amino acids comprising:
5-30, 10-25, 14-18, or around 16.7% L-Methionine;
10-50, 15-40, 20-30, or around 25% L-Cysteine;
10-50, 20-40, 26-32, or around 28% L-Cystine; or
any combination thereof.

### Claim 77 (depends on 63)

A method of enhancing hair density on a subject scalp of a subject having a condition associated with a reduced hair density compared to hair density in a subject without the condition, comprising:
preparing a hair serum formulation comprising the composition of claim 63;
administering a treatment regimen to the subject comprising applying a pharmacologically effective amount of the hair serum formulation to the subject scalp for an effective period of time; and
enhancing hair density on the subject scalp,
wherein hair density on the subject scalp of the subject administered the treatment regimen is enhanced compared to hair density on a subject scalp having a condition associated with reduced hair density without the treatment regimen.

### Claim 78 (depends on 77)

The method of claim 77 wherein the treatment regimen comprises:
one or more treatment cycles of administering an effective amount of around 1-10 ml, 2-8 ml, 3-5 ml, or around 4 ml of said hair serum formulation to the subject scalp, applied on the subject scalp at about 1 cm spaced intervals; and
massaging the scalp.

### Claim 79 (depends on 77)

The method of claim 77 wherein the treatment regimen comprises one or more treatment cycles of 2-10, 3-7, 4-6, or 5 consecutive days of treatment with said hair serum formulation to the subject scalp, followed by a period of 1-7, 2-4, 2 or 3 days without treatment with said hair serum formulation to the subject scalp.

### Claim 80 (depends on 77)

The method of claim 77 wherein the treatment regimen comprises:
around 60 consecutive days of application of the hair serum formulation to the subject scalp, followed by 30 to 60 days without application of the hair serum formulation to the subject scalp; or
8-10 treatment cycles of a 5-day application of the hair serum formulation to the subject scalp followed by 2 days without application of the hair serum formulation where the subject condition is an inherited hair thinning or inherited baldness condition.

### Claim 81

A method for preparing a composition suitable for use in treatment of a skin condition, comprising:
combining an amount of water and an amount of alcohol to provide a mixture; and
adding to the mixture one or more ingredients to provide the composition, wherein said ingredients comprise:
Cannabidiol (CBD);
Redensyl®;
Capixyl®; and
a C3 to C8 diol.

### Claim 82 (depends on 81)

The method of claim 81 wherein the composition comprises an amount of water suitable to formulate a hair serum comprising the composition.

### Claim 83 (depends on 81)

The method of claim 81 wherein the one or more ingredients added to the mixture comprise:
0.001-2.0, 0.05-0.5, 0.075-0.2, or around 0.1% CBD;
10-60, 30-55, 40-50, or around 30% EtOH;
0.5-5.0, 1.0-4.0, 1.5-2.5, or around 2% of a C3-C8 diol;
0.1-2.0, 0.2-1.0, 0.4-0.8, or around 0.6% menthol;
0.01-2.0, 0.1-1.5, 0.85-1.15, or around 0.9% of a skin healing compound comprising hyaluronic acid/hyaluronate;
0.01-2.0%,0.02-0.5, 0.04-0.07, or around 0.05% caffeine;
1.0-20, 2-10, 4-6, or around 5.0% propylene glycol;
1.0-20, 2-15, 5-8, or around 6.5% glycerin;
0.05-2.0, 0.1-1.0, 0.7-1.2, or 0.9% of a moisturizer, an emollient, a binder comprising Isopropyl palmitate, or any combination of a moisturizer, an emollient and a binder;
0.1-2.0, 0.15-1.0, 0.2-0.4, or around 0.28% triethanolamine;
0.0001-1.0, 0.0005-0.1, 0.001-0.003, or around 0.002% arginine;
0.5-5.0, 1.0-4.0, 2.5-3.0, or around 2.7% panthenol;
0.1-2.0, 0.2-1.5, 0.8-1.2, or around 1.0% of a vitamin B;
0.1-2.0, 0.15-1.0, 0.15-0.4, or around 0.25% of a thickening agent; or any combination thereof.