# US 2024/0189017 A1 · Pulse monitoring method, apparatus and device, and storage medium > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2024/0189017 A1 - Document ID: US20240189017A1 - Status: Published application - Kind: A1 - Application number: 18/587,394 - Filed: 2024-02-26 - Published: 2024-06-13 - Earliest claimed: 2021-09-01 - Assignees: Hangzhou Wknife Medical Technology Co., Ltd - Applicants: Hangzhou Wknife Medical Technology Co., Ltd. - Inventors: Xinghua ZHONG; Long WANG; Ke YANG - Web page: https://patentgrep.com/patent/US20240189017A1 ## CPC - A61B 18/14: Probes or electrodes therefor - A61B 18/1206: {Generators therefor} - A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)} - A61B 2018/00577: {Ablation} - A61B 2018/00642: {with feedback, i.e. closed loop control} - A61B 2018/00666: {using a threshold value} - A61B 2018/00672: {lower} - A61B 2018/00678: {upper} - A61B 2018/00702: {Power or energy} - A61B 2018/00708: {switching the power on or off} - A61B 2018/00767: {Voltage} - A61B 2018/00779: {Power or energy} - A61B 2018/00827: {Current} - A61B 2018/00875: {Resistance or impedance} - A61B 2018/00892: {Voltage} - A61B 2018/00898: {Alarms or notifications created in response to an abnormal condition} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A pulse monitoring method includes: applying a first pulse sequence and a second pulse sequence to target biological tissue; where a voltage of the second pulse sequence is smaller than a voltage of the first pulse sequence, and the first pulse sequence is used to ablate the target biological tissue; obtaining a feedback signal after the second pulse sequence is applied to the target biological tissue; determining, according to the feedback signal, whether a termination condition for the first pulse sequence is met; stopping applying the first pulse sequence when it is determined that the termination condition for the first pulse sequence is met. ## Claims ### Claim 1 A pulse monitoring method, comprising: applying a first pulse sequence and a second pulse sequence to target biological tissue; wherein a voltage of the second pulse sequence is smaller than a voltage of the first pulse sequence, and the first pulse sequence is used to ablate the target biological tissue; obtaining a feedback signal after the second pulse sequence is applied to the target biological tissue; determining, according to the feedback signal, whether a termination condition for the first pulse sequence is met; and stopping applying the first pulse sequence when it is determined that the termination condition for the first pulse sequence is met. ### Claim 2 (depends on 1) The pulse monitoring method according to claim 1, wherein applying the first pulse sequence and the second pulse sequence to the target biological tissue comprises: applying a first set quantity of first pulse sequences and a second set quantity of second pulse sequences to the target biological tissue sequentially and alternately. ### Claim 3 (depends on 1) The pulse monitoring method according to claim 1, wherein the first pulse sequence comprises at least one type of pulse and the second pulse sequence comprises at least one type of pulse. ### Claim 4 (depends on 1) The pulse monitoring method according to claim 1, wherein the first pulse sequence comprises a nanosecond pulse, or the first pulse sequence comprises a nanosecond pulse and a microsecond pulse; the second pulse sequence comprises a microsecond pulse. ### Claim 5 (depends on 4) The pulse monitoring method according to claim 4, wherein the voltage of the first pulse sequence is greater than 500V and not greater than 15 kV; and/or, the voltage of the second pulse sequence is not greater than 500V. ### Claim 6 (depends on 1) The pulse monitoring method according to claim 1, wherein obtaining the feedback signal after the second pulse sequence is applied to the target biological tissue comprises: obtaining a real-time voltage and a real-time current of a feedback circuit corresponding to the target biological tissue after the second pulse sequence is applied to the target biological tissue; wherein determining whether the termination condition for the first pulse sequence is met according to the feedback signal comprises: determining, according to the real-time voltage and real-time current of the feedback circuit, a real-time impedance value of the target biological tissue; determining whether the real-time impedance value is less than a set impedance value; or, displaying the real-time impedance value and determining whether a termination instruction for the first pulse sequence is received; and wherein stopping applying the first pulse sequence when it is determined that the termination condition for the first pulse sequence is met comprises: stopping applying the first pulse sequence when it is determined that the real-time impedance value is less than the set impedance value; or, stopping applying the first pulse sequence when it is determined that the termination instruction for the first pulse sequence is received. ### Claim 7 (depends on 6) The pulse monitoring method according to claim 6, wherein displaying the real-time impedance value comprises at least one of the following: displaying a real-time impedance value curve, wherein the real-time impedance value curve comprises at least two real-time impedance values in a set time period; or, displaying the real-time impedance value and corresponding biological indicator information of the target biological tissue; wherein the biological indicator information comprises at least one of the following: heart rate, blood pressure or blood oxygen concentration. ### Claim 8 (depends on 6) The pulse monitoring method according to claim 6, wherein displaying the real-time impedance value and determining whether the termination instruction for the first pulse sequence is received comprises: issuing an alarm prompt when the biological indicator information of the target biological tissue is greater than a set threshold, wherein the alarm prompt comprises emitting an alarm sound and/or outputting alarm information; outputting the termination instruction for the first pulse sequence in response to receiving the alarm information. ### Claim 9 A pulse monitoring device, comprising: a pulse generating circuit, a control unit and a monitoring unit; wherein, the control unit is communicatively connected to the pulse generating circuit, and configured to control the pulse generating circuit to apply a first pulse sequence and a second pulse sequence to target biological tissue; wherein a voltage of the second pulse sequence is smaller than a voltage of the first pulse sequence, and the first pulse sequence is used to ablate the target biological tissue; the control unit is further configured to determine, according to a feedback signal forwarded by the monitoring unit, whether a termination condition for the first pulse sequence is met, and output a termination instruction for the first pulse sequence to the pulse generating circuit when it is determined that the termination condition for the first pulse sequence is met; and the monitoring unit is communicatively connected to the control unit, and configured to obtain the feedback signal after the second pulse sequence is applied to the target biological tissue, and output the feedback signal to the control unit. ### Claim 10 (depends on 9) The pulse monitoring device according to claim 9, wherein the pulse generating circuit comprises a first pulse generating circuit for outputting the first pulse sequence and a second pulse generating circuit for outputting the second pulse sequence; wherein the first pulse generating circuit and the second pulse generating circuit are integrated on a same circuit board. ### Claim 11 (depends on 10) The pulse monitoring device according to claim 10, wherein the first pulse generating circuit comprises at least one level of first pulse generating units electrically connected sequentially; wherein each first pulse generating unit is electrically connected to the control unit, and configured to be turned on under control of the control unit and apply the first pulse sequence to the target biological tissue. ### Claim 12 (depends on 11) The pulse monitoring device according to claim 11, wherein each of the at least one level of first pulse generating units comprises a first capacitor, a first switching device and a first diode, a first terminal of the first capacitor is electrically connected to a first terminal of the first switching device, a positive electrode and a negative electrode of the first diode are electrically connected to a second terminal of the first capacitor and a second terminal of the first switching device respectively, and a control terminal of the first switching device is electrically connected to the control unit. ### Claim 13 (depends on 12) The pulse monitoring device according to claim 12, wherein the first pulse generating circuit further comprises at least one second diode; a first terminal of a first capacitor in a first level of first pulse generating unit in the at least one level of first pulse generating units is electrically connected to a first power source through the at least one second diode. ### Claim 14 (depends on 11) The pulse monitoring device according to claim 11, wherein the first pulse generating circuit further comprises at least one third diode, an anode and a cathode of the third diode are electrically connected to two adjacent first pulse generating units respectively. ### Claim 15 (depends on 11) The pulse monitoring device according to claim 11, wherein the second pulse generating circuit comprises at least one level of second pulse generating units electrically connected sequentially; wherein each second pulse generating unit is electrically connected to the control unit and configured to be turned on under control of the control unit and apply the second pulse sequence to the target biological tissue. ### Claim 16 (depends on 15) The pulse monitoring device according to claim 15, wherein the second pulse generating unit comprises a second capacitor, a second switching device and a fourth diode; a first terminal of the second capacitor is electrically connected to a first terminal of the second switching device, a positive electrode and a negative electrode of the fourth diode are electrically connected to a second terminal of the second capacitor and a second terminal of the second switching device respectively, and a control terminal of the second switching device is electrically connected to the control unit. ### Claim 17 (depends on 9) The pulse monitoring device according to claim 9, wherein the pulse monitoring device further comprises a display unit communicatively connected to the control unit, wherein the display unit is configured to display at least one of a real-time impedance value, a real-time impedance value curve or biological indicator information. ### Claim 18 (depends on 9) The pulse monitoring device according to claim 9, wherein the pulse monitoring device further comprises an alarm unit communicatively connected to the control unit, wherein the alarm unit is configured to issue an alarm prompt when the biological indicator information of the target biological tissue is greater than a set threshold. ### Claim 19 A non-transitory computer-readable storage medium having a computer program stored thereon, the computer program being executed by a pulse monitoring device to implement: applying a first pulse sequence and a second pulse sequence to target biological tissue; wherein a voltage of the second pulse sequence is smaller than a voltage of the first pulse sequence, and the first pulse sequence is used to ablate the target biological tissue; obtaining a feedback signal after the second pulse sequence is applied to the target biological tissue; determining, according to the feedback signal, whether a termination condition for the first pulse sequence is met; stopping applying the first pulse sequence when it is determined that the termination condition for the first pulse sequence is met. ### Claim 20 (depends on 19) The non-transitory computer-readable storage medium according to claim 19, wherein applying the first pulse sequence and the second pulse sequence to the target biological tissue comprises: applying a first set quantity of first pulse sequences and a second set quantity of second pulse sequences to the target biological tissue sequentially and alternately.