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US 2024/0185960 A1Published application
Computational fluid dynamics model and methods of use
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsAevelina Rahman, Bailey Cooper, Amardeep Singh Bhupender Bhalla
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Abstract
The present application provides methods for predicting freeze-thaw profiles across scales and geometries, producing predetermined freeze-thaw profiles in scaled-down experiments using a computational fluid dynamics model, and using scaled-down freeze-thaw profiles to predict at-scale freeze-thaw profiles.
Claims26
A method for freezing a solution, comprising:
- (a) using a computational fluid dynamics model to predict a first freezing profile of an at-scale volume of the solution subjected to first freezing operating conditions, wherein the first freezing profile includes predicted average temperatures of the solution during freezing and total freeze time;
- (b) using the computational fluid dynamics model to fit a transient temperature boundary equation to the first freezing profile;
- (c) using the computational fluid dynamics model to predict a set-temperature sequence that produces a predicted second freezing profile of the scaled-down volume of the solution, wherein:
- (i) the transient temperature boundary equation is a condition for predicting the set-temperature sequence;
- and
- (ii) the second freezing profile includes predicted average temperatures of the solution during freezing and total freeze time;
- and
- (d) freezing the scaled-down volume of the solution using the set-temperature sequence.
5 more elements
A method for thawing a solution, comprising:
- (a) using a computational fluid dynamics model to predict a first thawing profile of an at-scale volume of the solution subjected to first thawing operating conditions, wherein the first thawing profile includes predicted average temperatures of the solution during thawing and total thaw time;
- (b) using the computational fluid dynamics model to fit a transient temperature boundary equation to the first thawing profile;
- (c) using the computational fluid dynamics model to predict a set-temperature sequence that produces a predicted second thawing profile of the scaled-down volume of the solution, wherein:
- (i) the transient temperature boundary equation is a condition for predicting the set-temperature sequence;
- and
- (ii) the second thawing profile includes predicted average temperatures of the solution during thawing and total thaw time;
- and
- (d) thawing the scaled-down volume of the solution using the set-temperature sequence.
5 more elements
A method for freezing a solution, comprising:
- (a) using a computational fluid dynamics model to predict a freezing profile of the at-scale solution subjected to freezing operating conditions;
- (b) determining freezing will occur within a necessary period of time;
- and
- (c) freezing the at-scale volume of the solution using the freezing operating conditions.
1 more element
A method for thawing a solution, comprising:
- (a) using a computational fluid dynamics model to predict a thawing profile of the at-scale solution subjected to first thawing operating conditions;
- (b) determining thawing will occur within a necessary period of time;
- and
- (c) thawing the at-scale volume of the solution using the thawing operating conditions.
1 more element
Dependencies are inferred from the claim text.