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AssigneeNovartis AG
InventorsAsitha Adrian ABEYWARDANE, Tushar Dattu APSUNDE, Gianluca Nicolas ETIENNE, Alessia GAMBARDELLA, James Kevin MAINQUIST, Andrew J. MEYER, Brian MINIE, Steven PAULA, Dwayne A. L. VICKERS, Ken YAMADA
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The present disclosure generally relates to compositions, methods, sorters, systems, devices and uses for screening for bioactive substances in emulsion droplets. In some embodiments, the compositions are a continuous phase formulation for stable emulsions, In some embodiments, the methods are for preparing a monodisperse polyethylene glycol acrylamide (PEGA) co-polymer resin, or for preparing a core-shell bead. In some embodiments, the systems and devices include a sorter, comprising an inlet channel, first and second outlet channels meeting the inlet channel at a junction, and first and second electrodes proximate respective first and second sides of the junction sorter. In some embodiments, the systems and devices include a sorter, comprising a microwell array plate configured to host one microdroplet per microwell, a fluorescence microscope, an imager configured to automatically image assay droplets and identify desired droplets, and an automated microcapillary-based droplet sampling device configured to continuously deposit desired droplets to hit wells.
A continuous phase formulation for stable emulsions, comprising:
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A method of preparing a monodisperse polyethylene glycol acrylamide (PEGA) co-polymer resin, comprising:
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A method of preparing a thin-shell bead, comprising grafting hydrophilic polymer to the compound loaded, encoded core-bead.
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A core-shell bead obtained by a method, comprising:
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Dependencies are inferred from the claim text.