Microrna blockade for the treatment of disease
AssigneeYale University
InventorsJeffrey BENDER, Vinod RAMGOLAM, Timur YAROVINSKY
Life of this patent
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Abstract
In various aspects and embodiments the invention provides compositions and methods useful in the treatment of disease. In one aspect the invention provides a composition comprising a polynucleotide comprising one or more of SEQ ID NOS: 1-41 and at least one modification selected from the group consisting of locked nucleic acid, bridged nucleic acid, phosphorothioate nucleic acid, and peptide nucleic acid.
Claims17
A composition comprising a polynucleotide comprising one or more of SEQ ID NOS:
- 1-41 and at least one modification selected from the group consisting of locked nucleic acid, bridged nucleic acid, phosphorothioate nucleic acid and peptide nucleic acid.
A method of treating breast cancer in a subject in need thereof, the method comprising administering to the subject a polynucleotide comprising at least 5 consecutive nucleotides from SEQ ID NO:
- 2, SEQ ID NO:
- 39, SEQ ID NO:
- 40 or SEQ ID NO:
- 41.
A method of treating melanoma in a subject in need thereof, the method comprising administering to the subject a polynucleotide comprising at least 5 consecutive nucleotides from SEQ ID NO:
- 29, SEQ ID NO:
- 30, SEQ ID NO:
- 31 or SEQ ID NO:
- 32.
A method of treating a colorectal cancer in a subject in need thereof, the method comprising administering to the subject a polynucleotide comprising at least 5 consecutive nucleotides from SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 17 or SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 21 or SEQ ID NO:
- 22.
A method of treating cardiovascular disease in a subject in need thereof, the method comprising administering to the subject a polynucleotide comprising at least 5 consecutive nucleotides from SEQ ID NO:
- 27.
A method of treating a neurodegenerative disease in a subject in need thereof, the method comprising administering to the subject a polynucleotide comprising at least 5 consecutive nucleotides from SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 25, SEQ ID NO:
- 26, SEQ ID NO:
- 33, SEQ ID NO:
- 34, SEQ ID NO:
- 35, SEQ ID NO:
- 36, SEQ ID NO:
- 37 or SEQ ID NO:
- 38.
Dependencies are inferred from the claim text.