US 2024/0182840 A1 · DEVICE FOR CONTINUOUS VIRUS INACTIVATION

Abstract

Embodiments include a device for continuous virus inactivation during a protein production process comprising a first and a second fluid inlet, a first mixer, and a fluid outlet. A first liquid stream containing a target protein is introducible into the device through the first fluid inlet and is combinable in a predefined volume ratio with a second, virus-inactivating liquid stream introducible into the device through the second fluid inlet to form a third, reactive liquid stream which is conducted through the first mixer for mixing in order to generate predefined, virus-inactivating conditions. The device further comprises a head part and, downstream of the first mixer and upstream of the fluid outlet, a residence time arrangement fluidically connected to the head part for provision of a minimum residence time of the third stream, wherein the head part and the residence time arrangement are rigidly fastened to each other.

Claims31

Dependent claims

A device for continuous virus inactivation during a protein production process, comprising:

a first and a second fluid inlet, each configured to introduce a liquid stream into the device,
a first mixer, configured to mix a liquid stream, and
a fluid outlet, configured to discharge a liquid stream from the device, wherein, when the device is assembled as intended, a first liquid stream containing a target protein is introducible into the device through the first fluid inlet and is combinable in a precisely predefined volume ratio with a second, virus-inactivating liquid stream introducible into the device through the second fluid inlet to form a third, reactive liquid stream which is conducted through the first mixer for mixing in order to generate predefined, virus-inactivating conditions,
wherein the device comprises a head part for combination of two liquid streams, one of which is the liquid stream containing the target protein, wherein the device comprises, downstream of the first mixer and upstream of the fluid outlet, a residence time arrangement fluidically connected to the head part for provision of a minimum residence time of the third, reactive liquid stream within the device, wherein the head part and the residence time arrangement are rigidly fastened to each other, and wherein the head part is arranged on an end face of the residence time arrangement.

1 more element

Dependencies are inferred from the claim text.

Device for continuous virus inactivation

Life of this patent

Device for continuous virus inactivation

Life of this patent

Abstract

Claims31