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US 2024/0182832 A1Published application
Single vessel multi-zone bioreactor for simultaneous culture of multiple microbial strains
AssigneesRoyal Melbourne Institute of Technology, City University of Hong Kong
InventorsSrinivas METTU, Namita ROY CHOUDHURY, Naba Kumar DUTTA, Carol Sze Ki LIN, Zubeen HATHI
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Abstract
A single vessel multi-zone bioreactor for simultaneously culturing multiple microbial strains comprising multiple culturing zones arranged sequentially, each culturing zone comprising a porous hydrogel, and the use thereof for producing optionally encapsulated probiotics.
Claims16
A single vessel multi-zone bioreactor for simultaneously culturing multiple microbial strains comprising multiple culturing zones;
- wherein the multiple culturing zones are arranged sequentially to provide a sequence of at least three culturing zones;
- wherein the multiple culturing zones each comprise, a porous hydrogel, and a liquid culturing media;
- and wherein;
- a) the multiple culturing zones are arranged sequentially so as to provide a gradient in pH, from lower pH to higher pH, or from acidic pH to basic pH, or from higher pH to lower pH, or from basic pH to acidic pH;
- and/or
- b) the multiple culturing zones are arranged sequentially so as to provide a gradient in oxygen levels, from a higher partial pressure of oxygen to a lower partial pressure of oxygen, or from aerobic conditions to anaerobic conditions, or from a lower partial pressure of oxygen to a higher partial pressure of oxygen, or from anaerobic conditions to aerobic conditions.
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Dependencies are inferred from the claim text.