Anti-ige antibodies
AssigneeAbwiz Bio, Inc.
InventorsToshiaki Maruyama, Shigeru CJ Maruyama, Jiro Kitaura, Tomoaki Ando, Hexing Wang
Life of this patent
Estimating the term…
Abstract
This application concerns a set of anti-IgE antibodies to a novel region of Cε (β5-helix region of Cε2) and their use in the blocking of IgE to Fcε receptors (FcεRI and CD23) for the treatment of diseases mediated by IgE such as allergic airway diseases including asthma. Of note, these anti-IgE antibodies not only bind but also remove pre-bound IgE from Fcε receptors.
Claims30
An antibody or a fragment thereof, comprising a Fab region that specifically binds to an IgE, wherein the binding of the Fab to the IgE disrupts interaction between the IgE and at least one Fcε receptor.
Dependencies are inferred from the claim text.