Anti-muc1-c antibodies and car-t structures
AssigneeTeneoBio, Inc.
InventorsKatherine Harris, Brian Avanzino, Nathan Trinklein, Karen Chang, Nicole Allen
Life of this patent
Estimating the term…
Abstract
Anti-MUC1-C antibodies (e.g., UniAbs™) and CAR-T structures are disclosed, along with methods of making such antibodies and CAR-T structures, compositions, including pharmaceutical compositions, comprising such antibodies and CAR-T structures, and their use to treat disorders that are characterized by the expression of MUC1-C.
Claims53
An antibody that binds to MUC1-C, comprising a heavy chain variable region comprising:
- (a) a CDR1 sequence comprising two or fewer substitutions in any one of the amino acid sequences of SEQ ID NOs:
- 1 or 4;
- and/or
- (b) a CDR2 sequence comprising two or fewer substitutions in any one of the amino acid sequences of SEQ ID NOs:
- 2 or 5;
- and/or
- (c) a CDR3 sequence comprising two or fewer substitutions in any one of the amino acid sequences of SEQ ID NOs:
- 3 or 6.
An antibody that binds to MUC1-C, comprising a heavy chain variable region comprising CDR1, CDR2 and CDR3 sequences in a human VH framework, wherein the CDR sequences are sequences having two or fewer substitutions in a CDR sequence selected from the group consisting of SEQ ID NOs:
- 1-6.
An antibody that binds to MUC1-C, comprising a heavy chain variable region comprising:
- (a) a CDR1 sequence of SEQ ID NO:
- 1, a CDR2 sequence of SEQ ID NO:
- 2, and a CDR3 sequence of SEQ ID NO:
- 3, in a human VH framework;
- or
- (b) a CDR1 sequence of SEQ ID NO:
- 4, a CDR2 sequence of SEQ ID NO:
- 5, and a CDR3 sequence of SEQ ID NO:
- 6, in a human VH framework.
A bispecific three-chain antibody-like molecule (TCA) that binds to MUC1-C and CD3, comprising:
- (a) a first polypeptide consisting of SEQ ID NO:
- 32;
- (b) a second polypeptide selected from the group consisting of:
- SEQ ID NO:
- 33 and SEQ ID NO:
- 42;
- and
- (c) a third polypeptide selected from the group consisting of:
- SEQ ID NO:
- 34, SEQ ID NO:
- 35, SEQ ID NO:
- 36, SEQ ID NO:
- 37, SEQ ID NO:
- 38, and SEQ ID NO:
- 39.
A CAR-T cell comprising a CAR comprising an extracellular antigen-binding domain that binds to MUC1-C, comprising a heavy chain variable region comprising:
- (a) a CDR1 sequence of SEQ ID NO:
- 1, a CDR2 sequence of SEQ ID NO:
- 2, and a CDR3 sequence of SEQ ID NO:
- 3;
- or
- (b) a CDR1 sequence of SEQ ID NO:
- 4, a CDR2 sequence of SEQ ID NO:
- 5, and a CDR3 sequence of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.