Anti-cd74 antibody conjugates, compositions comprising anti cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates

An antibody conjugate comprising an antibody that specifically binds to CD74 linked site-specifically to at least one payload moiety, wherein the antibody comprises a non-natural amino acid at a site selected from the group consisting of HC-F404, HC-K121, HC-Y180, HC-F241, HC-221, LC-T22, LC-S7, LC-N152, LC-K42, LC-E161, LC-D170, HC-S136, HC-S25, HC-A40, HC-S119, HC-S190, HC-K222, HC-R19, HC-Y52, or HC-S70, according to the Kabat, Chothia, or EU numbering scheme, and wherein the antibody comprises three heavy chain CDRs and three light chain CDRs of a VH-VL pair selected from the group consisting of:

• a. the VH region SEQ ID NO:
• 236 and the VL region SEQ ID NO:
• 256;
• b. the VH region SEQ ID NO:
• 236 and the VL region SEQ ID NO:
• 257;
• c. the VH region SEQ ID NO:
• 236 and the VL region SEQ ID NO:
• 265;
• d. the VH region SEQ ID NO:
• 236 and the VL region SEQ ID NO:
• 264;
• e. the VH region SEQ ID NO:
• 236 and the VL region SEQ ID NO:
• 267;
• f. the VH region SEQ ID NO:
• 236 and the VL region SEQ ID NO:
• 268;
• g. the VH region SEQ ID NO:
• 236 and the VL region SEQ ID NO:
• 269;
• h. the VH region SEQ ID NO:
• 236 and the VL region SEQ ID NO:
• 270;
• i. the VH region SEQ ID NO:
• 237 and the VL region SEQ ID NO:
• 256;
• j. the VH region SEQ ID NO:
• 237 and the VL region SEQ ID NO:
• 257;
• k. the VH region SEQ ID NO:
• 237 and the VL region SEQ ID NO:
• 265;
• l. the VH region SEQ ID NO:
• 237 and the VL region SEQ ID NO:
• 264;
• m. the VH region SEQ ID NO:
• 237 and the VL region SEQ ID NO:
• 267;
• n. the VH region SEQ ID NO:
• 237 and the VL region SEQ ID NO:
• 268;
• o. the VH region SEQ ID NO:
• 237 and the VL region SEQ ID NO:
• 269;
• p. the VH region SEQ ID NO:
• 237 and the VL region SEQ ID NO:
• 270;
• q. the VH region SEQ ID NO:
• 238 and the VL region SEQ ID NO:
• 256;
• r. the VH region SEQ ID NO:
• 238 and the VL region SEQ ID NO:
• 257;
• s. the VH region SEQ ID NO:
• 238 and the VL region SEQ ID NO:
• 265;
• t. the VH region SEQ ID NO:
• 238 and the VL region SEQ ID NO:
• 264;
• u. the VH region SEQ ID NO:
• 238 and the VL region SEQ ID NO:
• 267;
• v. the VH region SEQ ID NO:
• 238 and the VL region SEQ ID NO:
• 268;
• w. the VH region SEQ ID NO:
• 238 and the VL region SEQ ID NO:
• 269;
• x. the VH region SEQ ID NO:
• 238 and the VL region SEQ ID NO:
• 270;
• v. the VH region SEQ ID NO:
• 239 and the VL region SEQ ID NO:
• 256;
• z. the VH region SEQ ID NO:
• 239 and the VL region SEQ ID NO:
• 257;
• aa. the VH region SEQ ID NO:
• 239 and the VL region SEQ ID NO:
• 265;
• bb. the VH region SEQ ID NO:
• 239 and the VL region SEQ ID NO:
• 264;
• cc. the VH region SEQ ID NO:
• 239 and the VL region SEQ ID NO:
• 267;
• dd. the VH region SEQ ID NO:
• 239 and the VL region SEQ ID NO:
• 268;
• ee. the VH region SEQ ID NO:
• 239 and the VL region SEQ ID NO:
• 269;
• ff. the VH region SEQ ID NO:
• 239 and the VL region SEQ ID NO:
• 270;
• gg. the VH region SEQ ID NO:
• 235 and the VL region SEQ ID NO:
• 256;
• hh. the VH region SEQ ID NO:
• 240 and the VL region SEQ ID NO:
• 256;
• and
• ii. the VH region SEQ ID NO:
• 241 and the VL region SEQ ID NO:
• 256.