Anti-pd-1 antibodies and uses thereof

One or more nucleic acids or polynucleotides encoding an antibody or fragment thereof having specificity to a human programmed cell death protein 1 (PD-1), wherein the antibody or fragment thereof comprises a heavy chain variable region comprising heavy chain complementarity determining regions HCDR1, HCDR2, and HCDR3, and a light chain variable region comprising light chain complementarity determining regions LCDR1, LCDR2, and LCDR3, wherein the HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3 are selected from the group consisting of:

• (SEQ ID NO:
• 18)
• (a) HCDR1:
• GFTFSSYT (SEQ ID NO:
• 1), HCDR2:
• ISHGGGDT (SEQ ID NO:
• 2),
• HCDR3:
• ARHSGYERGYYYVMDY (SEQ ID NO:
• 3), LCDR1:
• ESVDYYGFSF (SEQ
• ID NO:
• 4), LCDR2:
• AAS, LCDR3:
• QQSKEVPW (SEQ ID NO:
• 6);
• (b) HCDR1:
• GYTFTSYT (SEQ ID NO:
• 7), HCDR2:
• INPTTGYT (SEQ ID NO:
• 8),
• HCDR3:
• ARDDAYYSGY (SEQ ID NO:
• 9), LCDR1:
• ENIYSNL (SEQ ID NO:
• 10),
• LCDR2:
• AAK, LCDR3:
• QHFWGTPWT (SEQ ID NO:
• 12);
• and
• (c) HCDR1:
• GFAFSSYD (SEQ ID NO:
• 13), HCDR2:
• ITIGGGTT (SEQ ID NO:
• 14),
• HCDR3:
• ARHRYDYFAMDN (SEQ ID NO:
• 15), LCDRI:
• ENVDNYGINF (SEQ ID
• NO:
• 16), LCDR2:
• VSS, LCDR3:
• QQSKDVPW