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US 2024/0182545 A1Published application
Immunoglobulin fusion proteins
AssigneeUBI Pharma Inc. (UBIP)
InventorsChang-Yi Wang, Wen-Jiun Peng, Wei-Ting Kao
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Abstract
A fusion protein is disclosed. The fusion protein of the invention comprises an Fc fragment of an immunoglobulin G and a bioactive molecule, wherein the Fc is a single chain Fc. The amino acids in the hinge of the Fc is mutated, substituted, or deleted so that the hinge of Fc cannot form disulfide bonds. Methods for producing and using the fusion protein of the invention are also provided.
Claims19
A fusion protein comprising:
- (a) a bioactive molecule with a molecular weight of about 9,000 to about 70,000 daltons;
- (b) an Fc fragment portion of an IgG molecule having an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 61-64;
- and
- (c) a hinge region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 23-60, wherein the bioactive molecule and the Fc fragment portion are combined through the hinge region.
3 more elements
Dependencies are inferred from the claim text.