Polypeptides targeting dr4 and/or dr5 and related compositions and methods
OwnerJean-Philippe Julien, Edurne Rujas Diezinventors
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Abstract
A fusion protein comprises a nanocage monomer or a subunit thereof linked to a DR4 and/or DR5 antigen-binding moiety, wherein a plurality of the fusion proteins self-assemble to form a nanocage. Also described is a nanocage comprising the fusion protein and related compositions as well as methods and uses for treating and/or preventing cancer.
Claims37
A fusion protein comprising a nanocage monomer or a subunit thereof linked to a DR4 and/or DR5 antigen-binding moiety, wherein a plurality of the fusion proteins self-assemble to form a nanocage.
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