Antibody prodrugs with constant domains
AssigneesConcept To Medicine Biotech Co., Ltd., Lepu Biopharma Co., Ltd.
InventorsLei FANG, Hao SHEN, Peng ZENG
Life of this patent
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Abstract
Provided are antibody prodrugs that include an immunoglobulin superfamily constant region, such as CH3, or variant coupled to one or more chains of the antibody, optionally through a cleavable linker. It is discovered that the constant domain and variants serve as effective and safe masking moieties that inhibit the activity of the antibody. Once removed from the antibody, such as by a corresponding enzyme at a target treatment tissue, the antibody prodrug releases the active antibody. In tissues where no such enzyme is present, the antibody prodrug stays inactive, avoiding adverse effects in such tissues.
Claims27
A molecule comprising (a) an immunoglobulin superfamily constant region or a fragment thereof covalently coupled to (b) an immunoglobulin superfamily variable region, wherein the variable region, when not coupled to the constant region, can bind to a target molecule, but the coupling of the constant region to the variable region inhibits such binding.
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A fusion protein comprising a cleavable peptide linker fused to the C-terminus of an immunoglobulin superfamily constant region, wherein the fusion protein does not include an antigen-binding fragment on the N-terminal side of the immunoglobulin superfamily constant region.
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Dependencies are inferred from the claim text.