Bisphosphonate quinolone conjugates and uses thereof
AssigneeBiovinc, LLC
InventorsFrank H. EBETINO, Shuting SUN, Philip T. CHERIAN
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Abstract
Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.
Claims24
1-36. (canceled)
A compound comprising a bisphosphonate (BP) and a quinolone moiety, wherein the BP has an alpha carbon substituent (X) and wherein the quinolone moiety is directly or indirectly conjugated to the BP at the geminal bisphosphonate alpha carbon substituent (X) of the BP, the compound having the following structure:
- wherein R can be H, substituted and unsubstituted alkyl, alkyl amino, alkyl-aryl, aryl, alkylheteroaryl, or heteroaryl,
- wherein the quinolone moiety is releasably conjugated to the bisphosphonate by a linkage incorporating X,
- wherein the linkage incorporating X includes a carbonate linker, a carbamate linker, a thio carbamate linker, or a urea linker, and
- wherein the carbonate linker, carbamate linker, thio carbamate linker or urea linker is directly or indirectly coupled to the geminal carbon of the BP.
Dependencies are inferred from the claim text.