Azaheteroaryl compound, preparation method therefor, and application thereof
AssigneeShanghai Blueray Biopharma Co., Ltd.
InventorsShichao MA, Zhongguo ZHANG, Song ZHANG, Wenjia YUAN
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Abstract
The present invention provides an azaheteroaryl compound, a pharmaceutically acceptable salt thereof, and a solvate thereof. The present invention also provides a preparation method for such a compound, a composition containing such a compound, and a pharmaceutical use of such a compound in the preparation of a drug for treating a disease or disorder related to the mechanism of action of an EED protein and/or a PRC2 protein compound.
Claims20
A compound represented by formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a solvate thereof or their isotope-labeled derivative:
- wherein
- A is
- X is N or CR7;
- R1 is H, halogen, C1-4 alkoxy, unsubstituted C1-6 alkyl or C1-6 alkyl substituted by R3, an unsubstituted amino group or an amino group substituted by R4, unsubstituted C1-4 haloalkyl or C1-4 haloalkyl substituted by R3, unsubstituted C3-6 cycloalkyl or C3-6 cycloalkyl substituted by hydroxyl, or unsubstituted C3-6 heterocycloalkyl or C3-6 heterocycloalkyl substituted by R5;
- R2 is H, C1-4 alkyl, C3-6 cycloalkyl or an unsubstituted amino group or an amino group substituted by C1-4 alkyl;
- R3 is independently hydroxyl, carbonyl, —CN, halogen, C3-6 heteroaryl, unsubstituted C1-4 alkoxy or C1-4 alkoxy substituted by hydroxyl, an unsubstituted amino group or an amino group substituted by R6, C1-4 alkyl, C1-4 haloalkyl, C3-6 cycloalkyl or unsubstituted C3-6 heterocycloalkyl or C3-6 heterocycloalkyl substituted by C1-4 alkyl;
- R4 is independently carbonyl, C1-4 alkyl, C1-4 haloalkyl, C3-6 cycloalkyl or C3-6 heterocycloalkyl;
- R5 is independently C1-4 alkyl or C3-6 heterocycloalkyl;
- R6 is independently unsubstituted C1-4 alkyl or C1-4 alkyl substituted by R6-1;
- R6-1 is independently hydroxyl or an unsubstituted amino group or an amino group substituted by C1-4 alkyl;
- R7 is independently H, hydroxyl, —CN, halogen, C1-4 alkoxy or C1-4 alkyl;
- the number of R3 is 1, 2, 3 or 4;
- the number of R4 is 1 or 2;
- the number of R5 is 1, 2, 3 or 4;
- the number of R6 is 1 or 2;
- the heteroatom in the C3-6 heterocycloalkyl and C3-6 heteroaryl is selected from N, O and S, and the number of the heteroatom is 1, 2, 3 or 4;
- the compound represented by formula (I) is not
Dependencies are inferred from the claim text.