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US 2024/0182485 A1Published application
Process for preparing shp2 inhibitors
AssigneesGenzyme Corporation, Revolution Medicines, Inc.
InventorsMickaël ARNOLD, Steven G. BALLMER, Céline GARNIER, Jean-Pierre LESZCZAK, Shaoling LI
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Abstract
Provided herein are methods for preparing an SHP2 inhibitor and intermediates useful therein.
Claims26
A method of preparing a compound of Formula (6):
- or a salt thereof, comprising:
- reacting a compound of Formula (5):
- with an acid to form the compound of Formula (6) or a salt thereof.
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A method of preparing a compound of Formula (7), or a salt thereof, comprising the following steps:
A method of preparing a compound of Formula (4):
- or a salt thereof, comprising:
- reacting a compound of Formula (3):
- with an acid to form the compound of Formula (4) or a salt thereof.
A compound selected from the group consisting of Formula (1), Formula (2), and Formula (3):
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Dependencies are inferred from the claim text.