Substituted indazoles as irak4 inhibitors

A compound of Formula (I), or a pharmaceutically acceptable salt thereof,

• wherein:
• R1 is selected from
• R2 is selected from
• R3 and R4 are each independently selected from H, Me, Et, optionally substituted C1-C6 alkyl and optionally substituted C3-C6 cycloalkyl;
• Y is N(Me)COMe, N(R5)COMe, N(Me)COR6, N(R5)COR6, CONMe2 or a 5-membered N-heterocycle;
• and Z is H, Me, Et or optionally substituted C1-C6 alkyl;
• or
• Y and Z combine to form an optionally substituted 4-, 5- or 6-membered ring;
• X is selected from OR7 and NR8R9;
• R5 is selected from H, optionally substituted C1-C6 alkyl and optionally substituted C3-C6 cycloalkyl;
• R6 is selected from optionally substituted C1-C6 alkyl and optionally substituted C3-C6 cycloalkyl;
• R7 is Me, Et, i-propyl, n-propyl, cyclopropyl, cyclobutyl, an optionally substituted C1-C6 alkyl, C3-C6 cycloalkyl group or 4-, 5- or 6-membered ring containing an heteroatom selected from O and N;
• R8 and R9 are independently selected from H, Me and optionally substituted C1-C6 alkyl or together form an optionally substituted C3-C6 cycloalkyl or an optionally substituted 4-, 5- or 6-membered ring containing a further heteroatom selected from O and N;
• wherein the optional substituents of Z, R3, R4, R5, R6, R7, R8 and R9, when present, are independently selected from OH, C1-C3 alkyl, C1-C3 alkoxy, C(O)Me, amino, NHMe, NMe2, F and Cl.