Novel substituted pyrazine-carboxamide derivatives

A compound of formula I

• in which
• A represents C1-C6-alkyl, C3-C6-cycloalkyl, C3-C5-cycloalkyl-C1-C2-alkyl-, C1-C3-alkyl-O—C1-C3-alkyl-, 4-6-membered heterocycloalkyl-, or 4-6-membered heterocycloalkyl-C1-C3-alkyl-, which latter groups are optionally substituted with 1-4 substituents chosen from C1-C4-alkyl, C1-C4-alkoxy, hydroxy, fluoro;
• R1 represents C1-C7-alkyl, C1-C3-alkyl-O—C1-C3-alkyl-, C3-C7-cycloalkyl, 4-6-membered heterocycloalkyl, C3-C7-cycloalkyl-C1-C3-alkyl-, or 4-6-membered heterocycloalkylmethyl-, C5-C6-heterocycloalkylethyl-, which latter groups are optionally substituted with 1-4 substituents selected from the group consisting of from C1-C4-alkyl, C1-C4-alkoxy, C3-C7-cycloalkoxy, hydroxy, and fluoro;
• R2, R3, R4 and R5 independently of each other represent hydrogen, halogen, cyano, C1-C4-alkyl, C1-C3-alkyl-O—C1-C3-alkyl-, C3-C6-cycloalkyl, 4-6-membered C4-C6-heterocycloalkyl, C1-C4-alkoxy-, or C3-C6-cycloalkoxy-, wherein each of the cyano, C1-C4-alkyl, C1-C3-alkyl-O—C1-C3-alkyl-, C3-C6-cycloalkyl, 4-6-membered C4-C6-heterocycloalkyl, C1-C4-alkoxy-, or C3-C6-cycloalkoxy-groups is optionally substituted with 1-4 substituents selected from the group consisting of C1-C4-alkyl, C1-C4-alkoxy, hydroxy, and fluoro;
• provided that at least one of the groups R2, R3, R4 and R5 is not hydrogen;
• R6 represents halogen or C1-C3-alkyl optionally substituted with 2-3 fluorine atoms;
• or a physiologically acceptable salt thereof.