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US 2024/0182446 A1Published application
Tyk2 inhibitor compound containing bicyclic ring
AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.
InventorsFei Liu, Yanlong Liu, Bin Wang, Hongjiang Xu, Xujing Tang
Life of this patent
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Abstract
A TYK2 inhibitor compound containing a bicyclic ring and the use thereof in the preparation of a drug for treating or preventing TYK2-related diseases.
Claims18
A compound of formula I or a pharmaceutically acceptable salt thereof:
- wherein,
- X is selected from the group consisting of N and CH;
- each R1 is independently selected from halogen;
- q is selected from the group consisting of 0, 1, and 2;
- each R2 is independently selected from the group consisting of halogen, hydroxy, amino, cyano, and nitro;
- n is selected from the group consisting of 0, 1, and 2;
- T1, T2, T3, T4, and T5 are each independently selected from the group consisting of CH and N, at least one of which is selected from CH;
- ring A is selected from C3-10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-10 aryl, and 5- to 10-membered heteroaryl;
- each R3 is independently selected from the group consisting of ═O, halogen, hydroxy, amino, cyano, nitro, C1-8 alkyl, C3-10 cycloalkyl, 3- to 10-membered heterocycloalkyl, 5- to 10-membered heteroaryl, C6-10 aryl, and C1-8 alkoxy, wherein the C1-8 alkyl, C3-10 cycloalkyl, 3- to 10-membered heterocycloalkyl, 5- to 10-membered heteroaryl, C6-10 aryl, or C1-8 alkoxy is optionally substituted with one or more Ra;
- m is selected from the group consisting of 0, 1, 2, 3, and 4;
- each Ra is independently selected from the group consisting of halogen, hydroxy, amino, and cyano.
8 more elements
Dependencies are inferred from the claim text.