Novel compounds photo-crosslinked by visible light and uses thereof
AssigneeSeoul National University R&Db Foundation
InventorHyun Woo RHEE
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AssigneeSeoul National University R&Db Foundation
InventorHyun Woo RHEE
Estimating the term…
The present invention relates to novel compounds that are photo-crosslinked by visible light and spatiotemporal proximity photo-crosslinking by visible light activation (spotlight) using the same. When a target nucleic acid or target protein is bound to the novel compounds by the property of being photo-crosslinked to the proximal protein or peptide by irradiation with visible light and it is irradiated with visible light, the novel compounds according to the present invention can be photo-crosslinked with a protein or peptide that physically interacts with the target protein or target nucleic acid, and thus, there are advantages in that it is possible to overcome diffusive labeling, which is a limitation of the conventional proximity labeling technology, by photo-crosslinking by visible light irradiation, which is a safe method for a living body, and to improve the accuracy of protein interactome identification.
1-15. (canceled)
A compound represented by [Chemical Formula 1] below:
A method for photo-crosslinking a target protein or target nucleic acid with an interacting protein or peptide in proximity, comprising:
Dependencies are inferred from the claim text.