Quinoline compound salt or crystal form, preparation method therefor, and application thereof
AssigneeNanjing Zenshine Pharmaceuticals Co., Ltd.
InventorXiaolin Hao
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AssigneeNanjing Zenshine Pharmaceuticals Co., Ltd.
InventorXiaolin Hao
Estimating the term…
The present invention relates to the field of biomedicine; provided are a quinoline compound salt or a crystal form thereof, a preparation method therefor and an application thereof. The quinoline compound is as shown in Formula (I), and the provided salt may be used as an inhibitor of phosphoinositide 3-kinase for the treatment of diseases related to phosphoinositide 3-kinase. More particularly, the compound of Formula (I) may be 2,4-diamino-6-[1-(7-fluoro-2-pyridin-2-yl-quinolin-3-yl)-ethylamino]-pyrimidine-5-carbonitrile (Compound A), the structure thereof being as shown below. Crystal form I of p-toluenesulfonate of the compound may be used as an inhibitor of phosphoinositide 3-kinase for the treatment of diseases related to phosphoinositide 3-kinase.
A salt, characterized in that the salt is an organic acid salt or inorganic acid salt of a compound shown in Formula (I), wherein
A p-toluenesulfonate of Compound A, characterized in that the Compound A is:
A method for preparing a compound shown in Formula (I), characterized in that the method comprises:
A crystal form of p-toluenesulfonate of Compound A is characterized in that the crystal form is crystal form I,
Dependencies are inferred from the claim text.