Oral delivery of silica/aluminosilicate nanoparticles

A method of targeting, diagnosing, treating, preventing, or any combination thereof, a current or potential disease, disease state, condition, disorder, side effect, or any combination thereof, in an individual, the method comprising:

• orally administering one or more composition(s) to the individual, the composition(s) comprising a plurality of silica nanoparticles and/or aluminosilicate nanoparticles, wherein each silica nanoparticle or aluminosilicate nanoparticle independently comprises a silica core or an aluminosilicate core, respectively, and a plurality of PEG groups disposed on at least a portion of a surface or surfaces of the silica nanoparticle or the aluminosilicate nanoparticle, respectively, wherein the silica nanoparticles and/or the aluminosilicate nanoparticles have a longest linear dimension of about 20 nm or less, wherein at least a portion of the silica nanoparticles and/or the aluminosilicate nanoparticles are delivered to the post-stomach portion of the gastrointestinal tract of the individual and the current or potential disease, disease state, condition, disorder, side effect, or any combination thereof, is targeted, diagnosed, treated, prevented, or any combination thereof.

An oral delivery composition comprising:

• a plurality of silica nanoparticles and/or aluminosilicate nanoparticles, wherein each silica nanoparticle or aluminosilicate nanoparticle independently comprises a silica core or an aluminosilicate core, respectively, and a plurality of polyethylene glycol (PEG groups disposed on at least a portion of a surface or surfaces of the silica nanoparticle or the aluminosilicate nanoparticle, respectively, wherein the silica nanoparticles and/or the aluminosilicate nanoparticles have a longest linear dimension of about 20 nm or less;
• and
• one or more material(s) that render(s) the composition suitable for delivery of at least a portion of the silica nanoparticles and/or the aluminosilicate nanoparticles to the post-stomach portion of the gastrointestinal tract of an individual to whom the composition has been orally administered.