Back to results
US 2024/0181089 A1Published application
Pharmaceutical polymer conjugates
AssigneeXylonix Pte. Ltd.
InventorJinhyuk Fred Chung
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions for the intracellular delivery of therapeutically, active divalent metal ions, the compositions comprising a polypeptide having (i) one or more targeting moiety conjugated thereto, (ii) an ionophore conjugated thereto via a cleavable linker, and (iii) a divalent metal ion bound thereto, and methods for preparing such compositions, and their use in therapeutic methods.
Claims14
A polymer conjugate comprising:
- a polymer backbone comprising polyglutamic acid, which comprises glutamic acid monomer units joined by peptide bonds;
- a plurality of first receptor-targeting moieties, each covalently bonded to and pendant from a monomer unit in the polymer backbone via a first linker moiety;
- a plurality of ionophores, each covalently bonded to and pendant from a monomer unit in the polymer backbone via a cleavable linker moiety;
- or a salt or solvate thereof.
1 more element
A polymer conjugate according to Formula IV, V, or VI:
- or a metal ion complex thereof, wherein:
- R1 is H;
- R2 is OH or OM or LA-T1 or LB-T2 or LQ-Q;
- LA is a bond or bifunctional linking group having a first terminal site bonded to the polymer and a second terminal site bonded to T1 , wherein the first terminal site and the second terminal site are connected through a chain of 3 to 20 atoms;
- LB is a bond or bifunctional linking group having a first terminal site bonded to the polymer and a second terminal site bonded to T2,
- wherein the first terminal site and the second terminal site are connected through a chain of 3 to 20 atoms;
- LQ is bifunctional linking group having a first terminal site bonded to the polymer and a cleavable terminal site bonded to Q, wherein the first terminal site and the cleavable terminal site are connected through a chain of 3 to 20 atoms;
- LZ, when present, is a bond or bifunctional linking group having a first terminal site bonded to the polymer and a second terminal site bonded to Z, wherein the first terminal site and the second terminal site are connected through a chain of 3 to 20 atoms;
- T1 is a first targeting moiety;
- T2 is a second targeting moiety;
- Q is an ionophore moiety;
- Z, when present, is fluorophore moiety;
- each instance of M is independently H, a proton, an alkali ion;
- a pharmaceutically acceptable monovalent cation, or absent;
- a and b are zero or a finite number up to about 5, but a and b are not both zero;
- c is a finite number in the range from about 3 to about 50;
- d is, when present, approximately 1;
- and
- m is a finite number in the range from about 50 to about 700.
16 more elements
Dependencies are inferred from the claim text.