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US 2024/0181087 A1Published application
Composition for contrast imaging of cancer
AssigneesAstellas Pharma Inc., Mie University
InventorsKatsunori Teranishi, Hiroshi Fushiki
Life of this patent
Estimating the term…
Abstract
An object of the present invention is to provide a contrast agent capable of specifically identifying a cancer tissue. When a composition for contrast imaging of cancer containing a compound of the present invention is administered, a cancer tissue can be imaged with near-infrared light.
Claims14
A composition for contrast imaging of cancer, comprising a cyclodextrin-bonded indocyanine compound represented by formula (A), or a pharmaceutically acceptable salt thereof:
- wherein two Qs are each capable of being independently selected, are optionally the same or different, and are each *1-(CH2)a-CO—NH—(CH2)b-*3, wherein a is an integer of 2 or more and 6 or less, b is an integer of 2 or more and 6 or less, *1 in each Q is N of the indocyanine skeleton, and *3 is a bonding portion formed by replacing any one of three OH groups of any D-glucose contained in cyclodextrin with —O—;
- R1 to R23 each independently are a hydrogen atom, an alkyl group, an aryl group, a halogen atom, an alkoxyl group, an amino group, a carboxyl group, a formyl group, a sulfonyl group, a sulfonic acid group, a phosphoric acid group, an alkyloxycarbonyl group, an aryloxycarbonyl group, an alkylcarbonyl group, an arylcarbonyl group, or a heterocycle, R1 to R23 each independently are unsubstituted or substituted with a substituent, when the substituent is carboxylic acid, sulfonic acid, or phosphoric acid, a hydrogen ion is optionally dissociated from the substituent to be replaced with a metal ion;
- R8 and R9 optionally together form a cyclic structure of CH2, CH2CH2, CH2CH2CH2, or CH2CH2CH2CH2, and one or more hydrogen atoms of the cyclic structure is optionally substituted with an aryl group, a halogen atom, an alkoxy group, an amino group, a carboxyl group, a formyl group, a sulfonyl group, a sulfonic acid group, a phosphoric acid group, an alkyloxycarbonyl group, an aryloxycarbonyl group, an alkylcarbonyl group, an arylcarbonyl group, or a heterocycle.
-16. (canceled)
Dependencies are inferred from the claim text.