Method for Construction of Nucleic Acid Self-Assembly-Mediated ADC Drug and Use Thereof

Abstract

The present invention relates to the field of biotechnology drugs. In particular, provided in the present invention is an antibody-drug conjugate (ADC) complex based on a complementary and paired nucleic acid skeleton. The ADC complex is a polymer formed by means of compounding n monomers having complementary and paired nucleic acid skeletons, wherein the polymer contains: m “targeting monomers”, which are cell-surface-targeting antibodies or proteins linked to nucleic acid single strands, and k “drug monomers”, which are drugs (toxin payload) linked to nucleic acid single strands, n is a positive integer of 2-8, m is a positive integer of 1-3 and m<n, and k is a positive integer of 1−(n-m). In the polymer, each nucleic acid single strand of the monomer is complemented with a nucleic acid single strand of the other 1-3 monomers to form a complementary and paired double strand by means of base complementation, so that a complementary and paired nucleic acid skeleton structure is formed.

Dependencies are inferred from the claim text.