Anti-tim-3 antibodies and methods of use thereof
AssigneeAgenus Inc.
InventorsMarc VAN DIJK, Ekaterina Vladimirovna BREOUS-NYSTROM, Nicholas Stuart WILSON, Jeremy Dale WAIGHT, Dennis John UNDERWOOD
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Abstract
The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
Claims31
1-113. (canceled)
A method of increasing T cell activation in response to an antigen in a subject, the method comprising administering to the subject an effective amount of an antibody that specifically binds to human TIM-3, or a pharmaceutical composition comprising the antibody, wherein the antibody comprises a VH comprising the CDRH1, CDRH2, and CDRH3 amino acid sequences of the VH amino acid sequence of SEQ ID NO:
- 55, and a VL comprising the CDRL1, CDRL2, and CDRL3 amino acid sequences of the VL amino acid sequence of SEQ ID NO:
- 56.
Dependencies are inferred from the claim text.