Treating respiratory infections
AssigneeATH Therapeutics Inc.
InventorsLeslie Roy BERRY, Anthony Kam Chuen CHAN, William JACKSON, Attilio DIFIORE
Life of this patent
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Abstract
A method of treating or preventing a respiratory infection can include delivering aerosolized droplets of an antiviral solution to lung tissue of a subject, the antiviral solution including an aqueous carrier and an ATH conjugate that is solubilized in the aqueous carrier. The ATH conjugate includes antithrombin covalently bonded to heparin, the heparin including a polysaccharide chain having from about 15 to about 1,500 monosaccharide units.
Claims84
A method of treating respiratory infection, comprising delivering aerosolized droplets of an antiviral solution to respiratory tissue of a subject, the antiviral solution including an aqueous carrier and an ATH conjugate that is solubilized in the aqueous carrier, wherein the ATH conjugate includes antithrombin covalently bonded to heparin, the heparin including a polysaccharide chain having from about 15 to about 1,500 monosaccharide units.
The method of clam 1, wherein from about 0.01 mg to about 2 g of the ATH conjugate is delivered to respiratory tissue during a single treatment.
The method of clam 1, wherein from about 0.1 mg to about 2 g of the ATH conjugate is delivered to lung tissue during a single treatment.
The method of clam 1, wherein from about 5 mg to about 200 mg of the ATH conjugate is delivered to lung tissue during a single treatment.
A respiratory tissue treatment kit or device, comprising:
- an antiviral solution including an aqueous carrier and an ATH conjugate that is solubilized in the aqueous carrier, wherein the ATH conjugate includes antithrombin covalently bonded to heparin, the heparin including a polysaccharide chain having from about 15 to about 1,500 monosaccharide units;
- and
- an aerosolizing device loaded or loadable with the antiviral solution to form aerosolized droplets of the antiviral solution for delivery to respiratory tissue of a subject.
A respiratory tissue treatment kit or device, comprising:
- antiviral particles including ATH conjugate, wherein the ATH conjugate includes antithrombin covalently bonded to heparin, the heparin including a polysaccharide chain having from about 15 to about 1,500 monosaccharide units;
- and
- a dry medicament inhaler loaded or loadable with the antiviral providing a metered dose or multiple metered dosages of the antiviral particles for inhalation.
A method of treating infection, comprising delivering an antiviral composition to a subject, wherein the antiviral composition is in the form of an antiviral solution or antiviral particles, the antiviral composition including an ATH conjugate including antithrombin covalently bonded to heparin, the heparin including a polysaccharide chain having from about 15 to about 1,500 monosaccharide units.
The method of clam 69, wherein from about 0.1 mg to about 2 g of the ATH conjugate is delivered to the subject during a single treatment.
Dependencies are inferred from the claim text.