Poegma copolymer conjugates and methods of treating diseases

A method of treating a disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition, the composition comprising a plurality of conjugates, the conjugate comprising

• a biologically active agent;
• and
• a copolymer of poly[oligo(ethylene glycol) ether methacrylate] (POEGMA) conjugated to the biologically active agent, the copolymer of POEGMA comprising recurring units of formula (I)
• wherein
• X1 is of formula (II)
• or
• formula (III)
• wherein R1 and R2 are each independently hydrogen, alkyl, ester, C1-C4 alkylenyl-NH2, amide, carboxyl, or C1-C4 alkylenyl-OH, wherein the copolymer of POEGMA comprises about 1 molar % to about 99 molar % of recurring units with formula (II), about 1 molar % to about 99 molar % of recurring units with formula (III), and a weight average molecular weight of about 2 kDa to about 500 kDa, and
• wherein the conjugate has a transition temperature (Tt) of about 25° C. to about 37° C. at a concentration of about 1 uM to about 1 M, the plurality of conjugates self-assemble into an aggregate above the Tt of the conjugate, and the composition does not induce a histopathological change in the subject.