Methods for determining tumor immune status
AssigneeDuke University
InventorsSmita NAIR, Michael BROWN, David Ashley
Life of this patent
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Abstract
The present disclosure provides a method of measuring the production of a cytokine in a sample in response to an agonist to determine responsiveness of a patient to immunotherapy. The present disclosure also provides a method of treating a cancer patient with an oncolytic viral therapy when a sample from the patient has a certain level of anti-viral antibodies. Further, the present disclosure describes, in part, an immune competence blood test that allows for one skilled in the art to determine if a tumor is immunoproficient to respond to an immunotherapy.
Claims33
A method comprising:
- (a) contacting a patient sample with an innate immune agonist;
- and
- (b) measuring the level of at least one inflammatory cytokine,
- wherein the level of inflammatory cytokine production is indicative of responsiveness of the patient to an immunotherapy, wherein the patient has cancer and the immunotherapy comprises an anti-cancer immunotherapeutic.
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A method comprising:
- (a) obtaining a serum sample from a subject diagnosed with a cancer;
- (b) detecting the level of antibody specific to a viral antigen in the serum sample;
- (c) comparing the level of neutralizing antibodies in the sample to a reference level;
- and
- (d) treating the subject with an oncolytic viral therapy when the level of the neutralizing antibody in the sample is above the reference level.
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Dependencies are inferred from the claim text.