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US 2024/0180974 A1Published application
Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
AssigneeSynlogic Operating Company, Inc.
InventorsDean Falb, Jonathan W. Kotula, Vincent M. Isabella, Paul F. Miller, Suman Machinani, Saurabh Saha, Adam B. Fisher, Yves Millet, Ning Li
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Abstract
Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
Claims23
A genetically engineered non-pathogenic microorganism for intratumoral administration comprising one or more gene(s) or gene sequence(s) comprising one or more genes for depleting adenosine from the intratumoral site, wherein the gene sequence(s) is operably linked to an inducible promoter.
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Dependencies are inferred from the claim text.