Polypeptides targeting hla-a*11 and methods of use thereof
AssigneeA2 Biotherapeutics, Inc.
InventorsCarl Alexander Kamb, Agnes E. Hamburger
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Abstract
The disclosure relates to antigen binding domains that specifically bind to a major histocompatibility class I (MHC I) complex comprising an a chain encoded by HLA-A*11 alleles. The disclosure further relates to antibodies and receptors comprising said antigen binding domains, and their use in diagnostics and adoptive cell therapy.
Claims63
A polypeptide, comprising an antigen binding domain that specifically binds to a major histocompatibility class I (MHC I) complex comprising a human leukocyte antigen a chain encoded by an HLA-A*11 allele (HLA-A*11).
The receptor of any one of claims 36-41, comprising a transmembrane domain.
Dependencies are inferred from the claim text.