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US 2024/0180955 A1Published application
Fiber supplementation protects from antibiotic-induced gut microbiome dysbiosis by modulating redox metabolism
AssigneeBrown University
InventorsPeter Belenky, Swathi Penumutchu
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Abstract
The invention provides for the use of metformin or other mitochondrial complex 1 inhibitors with fiber probiotics to treat gut dysbiosis, especially antibiotic-induced gut dysbiosis (AID).
Claims11
A method of dietary fiber supplementation to alleviate antibiotic-induced gut dysbiosis in a patient when supplemented before, during, or after antibiotic treatment, comprising the step of administering to the patent a diet of plant-derived fibers and mitochondrial complex 1 inhibitors.
A diagnostic method, comprising the steps:
- (a) sequencing 16s RNA genes or metagenomic genes from the microbiome from fecal samples to provide a baseline microbiome;
- and
- (b) identifying patients as being amenable to gut dysbiosis therapy when the patients have higher levels of respiratory bacteria or other complex 1 utilizing bacteria in the patient's gastrointestinal tract;
- and
- (c) administering to the patent a diet of plant-derived fibers and mitochondrial complex 1 inhibitors.
2 more elements
Dependencies are inferred from the claim text.