Treatment of infectious diseases using bcl-2 family protein inhibitors
AssigneeTexas Biomedical Research Institute
InventorsLarry Schlesinger, Eusondia Arnett
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Abstract
Provided are methods of treating infectious diseases by administering a BCL-2 inhibitor and a MCL-1 inhibitor to a subject in need thereof. One such infectious disease is an infection of Mycobacterium tuberculosis. Also provided are methods of inhibiting the growth of Mycobacterium tuberculosis in a granuloma by contacting the granuloma with a BCL-2 inhibitor and a MCL-1 inhibitor.
Claims20
A method of treating an infection caused by an intracellular pathogen, the method comprising administering to a subject in need thereof a therapeutically effective amount of a BCL-2 inhibitor and a therapeutically effective amount of a MCL-1 inhibitor.
A method of treating a Mycobacterium tuberculosis infection, the method comprising administering to a subject in need thereof a therapeutically effective amount of a BCL-2 inhibitor and a therapeutically effective amount of a MCL-1 inhibitor.
A method of inhibiting growth of Mycobacterium tuberculosis in a granuloma, the method comprising contacting the granuloma with a therapeutically effective amount of a BCL-2 inhibitor and a therapeutically effective amount of a MCL-1 inhibitor.
Dependencies are inferred from the claim text.