Uses of fatty acid amide hydrolase inhibitors in treatment of trauma related psychiatric disorders
AssigneeNeuritek Ltd.
InventorsWilliam E. Hapworth, Alexander Neumeister
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Abstract
The present invention is directed to compositions containing a fatty acid amide hydrolase inhibitor and methods of use thereof for treatment of trauma-related psychiatric disorders in a patient in need thereof, particularly those that exhibiting hyperarousal symptomatology.
Claims30
A method of treating trauma-related psychiatric disorders in a patient in need thereof comprising the steps of (a) selecting a patient suffering from symptoms associated with said disorder, (b) administering to the patient effective amounts of a fatty acid amide hydrolase (FAAH) inhibitor, (c) identifying an improvement of at least one of the patient's symptoms from the baseline.
The method of claim 2, wherein the post-traumatic psychiatric disorder is selected from the group consisting of post-traumatic stress disorder (PTSD), post-traumatic anxiety disorder, post-traumatic depression, post-traumatic substance use disorders, and post-traumatic eating disorders, GDD and any combinations thereof.
A method of treating patients at risk of developing post-traumatic psychiatric disorder comprising the steps of (1) determining the patient's endophenotype, (2) among those identified in step (1), selecting those patients who exhibit at least one of the symptom selected from the group consisting of a) irritable behavior, (b) angry outbursts, (c) recklessness, (d) self-destructive behavior, (e) hypervigilance, (f) exaggerated startle response, (g) problems with concentration, (i) sleep disturbances or any combinations thereof, (3) administering to the patients identified in step (2) an effective amount of an FAAH inhibitor, (4) evaluating the patient's improvement of at least one the symptoms, and (5) continue administering the FAAH inhibitor to those patients who show improvement in at least one of the symptoms.
A method of treating anxiety, pain, depression associated with trauma comprising administering to a subject in need of such treatment an effective amount of a FAAH inhibitor.
A pharmaceutical unit form which comprises an immediate release and a delayed release component, wherein the immediate release component comprising a first therapeutic agent selected from the group consisting of a FAAH inhibitor, and the delayed release component comprising a second therapeutic agent that is selected from the group consisting of a serotonin reuptake inhibitors (SSRIs), a beta-adrenergic antagonist, an alpha 1 adrenergic antagonist, a benzodiazepine, an opiate compound, a cannabinoid compound, a cortisol lowering agent, an antagonist of N-methyl-D-aspartate (NMDA) receptors, a ventromedial prefrontal cortex enhancer and any combinations thereof.
Dependencies are inferred from the claim text.