Vaccine adjuvant

A method of treating or preventing a disease, disorder, condition to which an immune response is required, the method comprising administering to a subject in need thereof a therapeutically effective amount of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt or solvate thereof, to a subject receiving vaccine therapy.

A method of treating or preventing a disease, disorder, condition to which an immune response is required, the method comprising administering to a subject in need thereof a therapeutically effective amount of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt or solvate thereof, and a therapeutically effective amount of a vaccine.

A method of potentiating an immune response to a vaccine in a subject, the method comprising administering to a subject in need thereof a therapeutically effective amount of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt or solvate thereof, to a subject receiving vaccine therapy.

A method of potentiating the effect of a vaccine, the method comprising administering to a subject in need thereof a therapeutically effective amount of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt or solvate thereof, and a therapeutically effective amount of a vaccine.

A method of sensitising the immune system of a subject, the method comprising administering to a subject in need thereof a therapeutically effective amount of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt or solvate thereof, to a subject receiving vaccine therapy.

A method of sensitising the immune system of a subject, the method comprising administering to a subject in need thereof a therapeutically effective amount of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt or solvate thereof, and a therapeutically effective amount of a vaccine.

Use of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of a disease, disorder or condition to which an immune response is required.

Use of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use as a vaccine adjuvant.

Use of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use as an immune-sensitiser.

Use of N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use as an immune-potentiating agent.

A combination comprising N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101/zabinostat), or a pharmaceutically acceptable salt or solvate thereof, and a vaccine.