Methods of treating inflammation
AssigneeVeru Inc.
InventorsMitchell S. STEINER, Kester Gary BARNETTE
Life of this patent
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Abstract
The present invention relates to methods of treating inflammation using compounds that disrupt the cytoskeleton by causing microtubule depolymerization and preventing or reducing the assembly of activated inflammasomes.
Claims23
A method of treating inflammation in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound of Formula (I):
- wherein
- A is phenyl, indolyl, or indazolyl, optionally substituted with at least one of (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O—(C1-C4)haloalkyl, (C1-C4)alkylamino, amino(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, NH2, hydroxyl, OC(O)CF3, —OCH2Ph, —NHCO—(C1-C4)alkyl, COOH, —C(O)Ph, C(O)O—(C1-C4)alkyl, C(O)H, —C(O)NH2 or NO2;
- B is an imidazole or benzimidazole, optionally substituted with at least one of (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O-halo(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, hydroxyl, or NO2;
- R1, R2 and R3 are independently at least one of hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O—(C1-C4)haloalkyl, (C1-C4)alkylamino, amino(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, NH2, hydroxyl, OC(O)CF3, —OCH2Ph, —NHCO—(C1-C4)alkyl, COOH, —C(O)Ph, C(O)O—(C1-C4)alkyl, C(O)H, —C(O)NH2 or NO2;
- X is a bond or NH;
- Y is —C═O;
- and
- m is 1-3, or a pharmaceutically acceptable salt, hydrate, polymorph, or isomer thereof.
A method of treating inflammation in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound of the Formula VII:
- wherein
- X is a bond or NH;
- Q is NH and
- A is a phenyl, indolyl, or indazolyl ring optionally substituted with at least one of (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O—(C1-C4)haloalkyl, (C1-C4)alkylamino, amino(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, NH2, hydroxyl, OC(O)CF3, —OCH2Ph, —NHCO—(C1-C4)alkyl, COOH, —C(O)Ph, C(O)O—(C1-C4)alkyl, C(O)H, —C(O)NH2 or NO2;
- or a pharmaceutically acceptable salt, hydrate, polymorph, or isomer thereof.
A method of treating inflammation in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound of the Formula VII(c):
- wherein
- R4 and R5 independently hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O—(C1-C4)haloalkyl, (C1-C4)alkylamino, amino(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, NH2, hydroxyl, OC(O)CF3, —OCH2Ph, —NHCO—(C1-C4)alkyl, COOH, —C(O)Ph, C(O)O—(C1-C4)alkyl, C(O)H, —C(O)NH2 or NO2;
- and
- n is 1-4;
- or a pharmaceutically acceptable salt, hydrate, polymorph, or isomer thereof.
A method of treating inflammation in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound 17ya represented as:
Dependencies are inferred from the claim text.