Inhibitor for retinochoroidal disorders
AssigneeYamaguchi University
InventorKazuhiro KIMURA
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Abstract
The present invention addresses the problem of providing an inhibitor for retinochoroidal disorders, in particular, an inhibitor for retinochoroidal scar formation and retinochoroidal atrophy in an epiretinal, intraretinal or subretinal tissue. This problem can be solved by preparing an inhibitor for retinochoroidal disorders which comprises, as an active ingredient, (E)-4-(2-{3-[(1H-pyrazol-1-yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-yl}vinyl)benzoic acid, an ester thereof or a salt of the same. The inhibitor for retinochoroidal disorders can inhibit collagen atrophy of retinal pigment epithelium cells, fibroblasts, glial cells and the like and thus inhibit retinochoroidal disorders.
Claims18
A method of inhibiting or reducing atrophy of a retinochoroidal scar in the retina and/or choroid of a subject in need thereof, comprising administering to the subject palovarotene ((E)-4-(2-{3-[(1H-pyrazole-1-yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-yl}vinyl) benzoic acid), an ester thereof, or a salt thereof, in an amount effective to inhibit or reduce atrophy of the retinochoroidal scar.
Dependencies are inferred from the claim text.