Nanoformulations of Pazopanib, Compositions Comprising the Same and Methods of Treating Osteoarthritis
AssigneesThe United States Government as represented by the Department of Veterans Affairs, The Board of Trustees of the University of Illinois
InventorsHee-Jeong Im Sampen, Ying Liu
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Abstract
Disclosed herein are nanoparticles comprising Pazopanib or a derivative thereof encapsulated by the copolymer poly(lactic-co-glycolic acid) (PLGA). Also disclosed herein are methods for treating osteoarthritis, inhibiting or preventing cartilage degeneration, and reducing or inhibiting pain-associated depression in subjects with joint pain with nanoparticles comprising Pazopanib or a derivative thereof.
Claims38
A nanoparticle comprising or consisting of Pazopanib encapsulated by the copolymer poly(lactic-co-glycolic acid) (PLGA).
The nanoparticle of any of the preceding claims, wherein the nanoparticle further contains a positively charged molecule or a positively charged lipid.
A composition comprising two or more nanoparticles of any of the preceding claims.
Dependencies are inferred from the claim text.