Thin-shell polymeric nanoparticles and uses thereof
AssigneeAcademia Sinica
InventorsChe-Ming Jack Hu, Hui-Wen Chen, Bing-Yu Yao
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Abstract
A polymeric nanoparticle that has a size of 30-600 nm in outer diameter and contains a polymeric shell, less than 25 nm in thickness and impermeable to water, one or more aqueous cores enclosed by the polymeric shell, and a bioactive agent encapsulated in each of the one or more aqueous cores. Also disclosed are a method of preparing the polymeric nanoparticle and a method of using it for treating a disease.
Claims22
A polymeric nanoparticle for encapsulating a bioactive agent, the polymeric nanoparticle comprising:
- a polymeric shell impermeable to water, and
- one or more aqueous cores enclosed by the polymeric shell, the one or more aqueous cores each containing the bioactive agent,
- wherein the polymeric shell has a thickness less than 25 nm and the polymeric nanoparticle has an outer diameter of 30-600 nm.
2-4. (canceled)
(canceled)
A method of treating a disease, comprising administering to a subject in need thereof a polymeric nanoparticle encapsulating a bioactive agent for treating the disease, wherein the polymeric nanoparticle includes a polymeric shell impermeable to water, and one or more aqueous cores enclosed by the polymeric shell, the one or more aqueous cores each containing the bioactive agent, in which the polymeric shell has a thickness less than 25 nm and the polymeric nanoparticle has an outer diameter of 30-600 nm.
Dependencies are inferred from the claim text.