Thermally Stable Vaccine Formulations Utilising Metal Organic Framework (MOF) Shells
OwnerRuhani Singh, Daniel Layton +1inventors
InventorsRuhani Singh, Daniel Layton, Cara Doherty
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Abstract
The present application relates to metal-organic framework (MOF) encapsulation or viral vaccines and vectors. The present application discloses methods for stabilizing viral vaccines and vectors and provides MOF encapsulated viral vaccines and vectors with improved stability.
Claims38
A stabilized composition comprising a live viral vaccine, a live-attenuated viral vaccine, an inactivated viral vaccine, a chimeric viral vaccine, a virus like particle vaccine, or a viral vector encapsulated within a Metal Organic Framework (MOF) shell.
A method for producing a stabilized composition, the method comprising:
- a. providing a live viral vaccine, a live-attenuated viral vaccine, an inactivated viral vaccine, a chimeric viral vaccine, a virus like particle vaccine, or a viral vector;
- b. providing a ligand precursor;
- c. providing a metal salt;
- d. reacting the vaccine or vector, the ligand precursor and the metal salt to form a metal organic framework shell encapsulating the vaccine or vector.
Dependencies are inferred from the claim text.