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US 2024/0180838 A1Published application
Nanoparticle (np) compositions and methods of use thereof
AssigneeRutgers, The State University of New Jersey
InventorsMaricely Ramirez Hernandez, Tewodros Asefa, Jeffrey M. Boyd, Javiera Norambuena-Morales
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Abstract
The present disclosure relates to compositions and methods for treating a wound, or location of interest, in a subject by topically administering to the subject a therapeutic composition of the present disclosure. The composition of the disclosure comprises nanoparticle (NP) composites for delivering at least two cargos to the wound. In certain embodiments, the at least two cargos comprise a metal and a small molecule drug.
Claims20
A nanoparticle (NP) functionalized with at least one pH-responsive moiety, wherein:
- (a) at least two cargos are associated with the NP and/or the at least one pH-responsive moiety,
- wherein each cargo is independently selected from the group consisting of a therapeutic cargo, a molecular marker, and a biomarker;
- and
- (b) swelling of at least one the pH-responsive moiety allows for release of the at least two cargos associated with the NP and/or at least one pH-responsive moiety.
1 more element
Dependencies are inferred from the claim text.