Cationic Lipid Compound and Composition for Delivery of Nucleic Acids and Use Thereof

A cationic lipid compound having the structure of formula (I):

• or pharmaceutically acceptable salts, tautomers or stereoisomers thereof, for delivery of nucleic acids,
• wherein:
• L1 is any one of —C(═O)—, —OC(═O)—, —C(═O)O—, —OC(═O)O—, —O—, —S—, —S—S—, —C(═O)S—, —SC(═O)—, —N(R6)C(═O)—, —C(═O)N(R6)—, —N(R6)C(═O)O—, —OC(═O)N(R6)—, —SC(═O)N(R6)—, —N(R6)C(═O)S—, —C(═S)—, —SC(═S)— and —C(═S)S—, and R6 is H or a C1-C12 alkyl;
• G1 and G2 are each independently a C3-C10 alkylene;
• R1 is a C2-C12 alkyl;
• R2 is H or a C2-C12 alkyl;
• R3 is a C2-C12 alkyl;
• R4 is H or a C2-C12 alkyl;
• R5 is H, a C1-C6 alkyl, —R7—OH, —R7—OC(═O)CH3, —R7—NHC(═O)—CH3, —R7—OCH3 or —R7—NR8(R9);
• R7 is a C2-C18 alkylene;
• R8 and R9 are C1-C8 straight chain alkyl groups, or R8, R9 and the N atom attached thereto form a C3-C10 heterocyclic group.