Sterically stabilized carrier compositions for treating a mammal
AssigneeVgsk Techologies, Inc.
InventorsKameswari S. Konduri, Nejat Duzgunes, Jogi Pattisapu, Ram Pattisapu
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Abstract
Disclosed herein are pharmaceutical compositions and methods for oral or sublingual administration comprising sterically stabilized liposome carriers which release in different pHs in a subject. Compositions and methods for treatment of allergies, eosinophilic esophagitis, inflammation, tuberculosis and other diseases are also described.
Claims20
A method for treating inflammation associated with an allergy or a disease in a subject in need thereof, the method comprising administering, orally or sublingually, (1) a first active agent encapsulated in a first liposome carrier that comprises:
- i) poly (ethylene glycol) distearoylphosphatidylethanolamine (PEG-DSPE), ii) phosphatidylglycerol, phosphatidylcholine, or a combination thereof, and a pH sensitive component which causes the liposome to release the first active agent in a pH range of about pH 1 to about pH 5;
- and (2) a second active agent encapsulated in a second liposome carrier that comprises:
- i) poly (ethylene glycol) distearoylphosphatidylethanolamine (PEG-DSPE), ii) phosphatidylglycerol, phosphatidylcholine, or a combination thereof, wherein the second liposome carrier releases the second active agent in a pH range of about pH 6 to about pH 8.
Dependencies are inferred from the claim text.