Laquinimod formulation for ocular use
AssigneeActive Biotech AB
InventorsHans Wännman, Marie Törngren, Helena Eriksson, Andreas Buhl
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Abstract
A pharmaceutical formulation comprising laquinimod or a pharmaceutically acceptable salt thereof as active ingredient, a pharmaceutically acceptable viscosity agent, a pharmaceutically acceptable tonicity adjusting agent, a pharmaceutically acceptable humectant, a pharmaceutically acceptable antioxidant, and a pharmaceutically acceptable pH regulating agent. The formulation is suitable for the treatment of ocular diseases by ocular administration, preferably topical ocular administration.
Claims28
A formulation for ocular administration comprising, in an aqueous phase:
- (i) a therapeutically effective amount of laquinimod or a pharmaceutically acceptable salt thereof as active ingredient,
- (ii) a pharmaceutically acceptable viscosity agent in an amount sufficient to provide a dynamic viscosity of 2 to 200 mPas, as measured at 20° C.,
- (iii) a pharmaceutically acceptable tonicity adjusting agent, in an amount sufficient to provide an osmolality of 200 to 600 mOsm/kg,
- (iv) a pharmaceutically acceptable humectant,
- (v) a pharmaceutically acceptable antioxidant, and
- (vi) a pharmaceutically acceptable pH regulating agent.
-25. (canceled)
-28. (canceled)
Dependencies are inferred from the claim text.