System, apparatuses, devices, and methods for an analyte diffusive implantable device

An analyte diffusive system comprising:

• an analyte diffusive implantable device (ADID) which comprises:
• a cavity;
• a cell-scaffolding material (CSM) arranged within the cavity and configured to hold or otherwise retain a plurality of living cells;
• and
• a porous membrane at least partially enclosing the cavity, wherein at least a portion of the membrane is adhered to the CSM by a high durometer adhesive which creates a hemispheric seal at both ends of the membrane;
• and
• a filling port configured for connection to an end of the device, wherein the port is configured:
• to be in communication with the cavity and sealed thereto,
• to provide access to the cavity to enable cells to be received in the cavity, and
• as a polymer molded structure so as to allow an injection system to seal to thereto.

An aseptic transferring method for transferring or otherwise moving an implantable device or system, the method comprising:

• providing an analyte diffusive implantable device (ADID)
• providing a clip;
• holding the device with the clip, wherein the clip attaches to the device either at one end of the device or via an anchor attached to the end of the device;
• and
• moving the device via the clip through automated manufacturing unit operations to fill the device

An aseptic method to maintain orientation of a device or system during storage and use for a surgical implant, the method comprising

• providing an analyte diffusive system including an analyte diffusive implantable device (ADID);
• providing a clip;
• holding the ADID with the clip, wherein the clip attaches to the ADID either at one end of the ADID or via an anchor attached to the end of the ADID and orients the ADID vertically and centrally in a packaging system containing cell nutrient media;
• and
• optionally aseptic transferring of the ADID from the packing system to a sclerotomy incision and facilitating positioning of the ADID and release of the ADID into the incision and vitreous cavity.