Method and device for inducing hypometabolic state in subject with disease

An apparatus that stimulates a pyroglutamylated RFamide peptide (QRFP)-producing neuron within one or more regions selected from the group consisting of an anteroventral periventricular nucleus (AVPe), a medial preoptic area (MPA), and a periventricular nucleus (Pe) in a brain of a living subject, wherein the subject has a disease, and

• the apparatus comprises:
• a control unit that transmits a control signal controlling voltage generation;
• a voltage generation unit that receives the control signal from the control unit and generates a voltage;
• a stimulation probe electrically connected proximally to the voltage generation unit and comprising an electrical stimulation electrode distally wherein the stimulation probe has a length sufficient to access the QRFP-producing neuron from a brain surface, and generates an electrical stimulus at a distal electrical stimulation electrode with the voltage from the voltage generation unit;
• an outside air temperature gauge;
• a deep body thermometer;
• a gas analysis unit that measures an oxygen concentration of each of exhaled gas and inhaled gas;
• a recording unit that records a measured outside air temperature and at least one numerical value selected from the group consisting of a deep body temperature and the oxygen concentration;
• a computation unit that calculates an oxygen consumption of the subject from an oxygen concentration difference between exhaled air and inhaled air from the subject;
• a hibernation possibility estimation unit that estimates that the subject has entered a hibernation-like state or may have entered a hibernation-like state at least based on a decrease in both oxygen consumption and theoretical setpoint temperature compared with an oxygen consumption and a theoretical setpoint temperature of the subject in a non-hibernation-like state;
• and
• a death possibility estimation unit that estimates that the subject is dead or may be dead at least when the oxygen consumption is zero.