Integrated sweat sensing system for health status monitoring and safety warning

An integrated sweat sensing system comprising a multi-layered structure, the multi-layer structure comprising:

• an adhesive layer for enhancing adhesion of the integrated sweat sensing system to a contact surface of human skin of a user;
• a sensing layer comprising:
• a flexible printed circuit board (FPCB), on which a plurality of electronic and mechanical components is disposed comprising at least a mechanical actuator for outputting a vibrating signal to the user, a microcontroller (MCU), and a plurality of feedback signal outputs each generating at least two opposing visual, audio or audio-visual signals representing at least two different states of each corresponding detectable biological, chemical or physiological signal by a corresponding biosensor;
• and
• a biomarker sensing platform having a plurality of biosensors associated with an electrode layer and a microfluidics, the microfluidics comprising a plurality of microchambers, a microfilter being an interface between the microfluidics and the human skin contact surface, and a plurality of microchannels connecting corresponding microchambers together and connecting microchambers with the microfilter, the microchambers being disposed at where matching where the biosensors are disposed on the biomarker sensing platform in order to provide a shortest path for the sweat of the user to flow through from the human skin contact surface to the corresponding biosensors and avoid any contaminants to the sweat;
• and
• an encapsulation layer.