Perfusion measurement with low field nmr
AssigneeWellumio Limited
InventorsSergei OBRUCHKOV, Alice LITTLE
Life of this patent
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Abstract
The present disclosure relates to the field of medical applications. In particular, to a measurement system and method for non-invasive detection and monitoring of physiological parameters, in particular perfusion, to provide clinically relevant information through Nuclear Magnetic Resonance (NMR) observation.
Claims30
A perfusion measurement system comprising:
- a magnetic structure configured to receive a body part of an examined subject and to create an inhomogeneous static magnetic field within a test tissue of the examined subject;
- means to apply a first inversion recovery radiofrequency (RF) pulse sequence and a second inversion recovery RF pulse sequence to the test tissue, wherein an inversion pulse of the first or second pulse sequences has a different bandwidth than a corresponding inversion pulse of the other of the first or second pulse sequence;
- and
- acquisition means to acquire magnetic resonance signal data from the pulse sequences and process the magnetic resonance signal data to provide perfusion data.
The perfusion measurement system as claimed in any one of the preceding claims wherein the bandwidth of the inversion recovery RF pulse sequences other than the inversion pulses is substantially the same.
The perfusion measurement system as claimed in any one of the preceding claims wherein the inversion pulse for the first inversion recovery RF pulse sequence has a narrower bandwidth than the inversion pulse for the second inversion recovery RF pulse sequence.
The perfusion measurement system as claimed in any one of the preceding claims wherein the inversion pulse comprises or is configured as a composite pulse.
The perfusion measurement system as claimed in any one of the preceding claims, wherein the system is portable.
A method for measuring perfusion comprising:
- applying an inhomogeneous static magnetic field to a test tissue of an examined subject;
- applying a first inversion recovery RF pulse sequence and a second inversion recovery RF pulse sequence to the test tissue, wherein an inversion pulse of the first or second pulse sequences has a different bandwidth than a corresponding inversion pulse of the other of the first or second pulse sequence;
- acquiring magnetic resonance signal data from the pulse sequences and processing the magnetic resonance signal data to provide perfusion data.
Dependencies are inferred from the claim text.